Date: February 12, 2013 By:
Studying infectious diseases has long been primarily the domain of biologists. However, as part of the Ragon Institute, MIT engineers and physical scientists are joining immunologists and physicians in the battle against HIV, which currently infects 34 million people worldwide.
The mission of the Ragon Institute — launched jointly in 2009 by Massachusetts General Hospital (MGH), MIT and Harvard University — is to develop new HIV vaccines through better understanding of how the immune system responds to infection. Bruce Walker, the MGH physician who directs the institute, says it was important to enlist engineers and physical scientists, who have usually been excluded from traditional HIV research, to help in this effort.
“It seemed to me that if we could break down some of those silos, there were probably tools in the toolbox that could be applied to the problem right now that weren’t being applied,” Walker says. “MIT has brought a lot to the table — not only expertise, but also a different way of thinking about approaching problems.”
Read more via Infection Control Today
Their findings, to be published in Cell next month, reveal how the virus manipulates immune system processes to avoid destruction by natural killer (NK) cells, a type of white blood cell that is crucial for fighting viral infections.
The lab of the Ragon Institute faculty member Hernandez Moura Silva, PhD, recently published a review in Science Immunology regarding resident tissue macrophages (RTMs), shedding light on their multifaceted roles in organ health.
After three years off due to the COVID-19 pandemic, the Ragon-MIT course HST.434 returned this January to provide 24 students a once in a lifetime learning experience