James B. Whitney, PhD

Lab Info:

Principal Investigator: James B. Whitney, PhD

Office/Location: BIDMC

Phone: (617) 735-4531

Email: jwhitne2@bidmc.harvard.edu

Category: Associate Members

Dr. James B. Whitney received his Ph.D. in Virology from McGill University in Montreal, Canada. He did his post-doctoral training at The Beth Israel Deaconess Medical Center and Harvard Medical School where he studied viral transmission and evolutionary dynamics in the setting of T cell vaccination. He is currently an Assistant Professor and the Principal Investigator of the Viral Dynamics laboratory at the Center for Virology and Vaccine Research at the BIDMC.


His laboratory focuses on viral dynamics, the HIV-1/SIV viral reservoir and the development of novel HIV-1 eradication strategies. In collaboration with Industry partners, his group has developed a novel non-human primate model to study viral dynamics and the nature of the SIV reservoir under potent anti-retroviral therapy. In parallel, they are also evaluating a number of pre-clinical therapeutic modalities to reduce the reservoir burden in vivo.


Selected Publications

Barouch DH, Whitney JB, Moldt B, Klein F, Olivera TY, Shekhar K, Gupta S, Liu J, Nkolola JP, Seaman MS, Smith KM, Borducchi EN, Cabral C, Smith JY, Blackmore S, Bajimaya S, Beck M, Lewis MG, Ferguson M, Chakraborty AK, Poignard P, Nussenzweig MC, Burton DR Therapeutic Efficacy of Potent Neutralizing HIV-1-Specific Monoclonal Antibodies in SHIV-Infected Rhesus Monkeys. Nature. 2013 Nov 14;503(7475):224-8.


Whitney JB, Hill AL, Sanisetty S, Penaloza-MacMaster P, Liu J, Shetty M, Parenteau L, Cabral C, Shields J, Blackmore S, Smith JY, Brinkman AL, Peter LE, Mathew SI, Smith KM, Borducchi EN, Rosenbloom D, Lewis MG, Hattersley J, Li B, Hesselgesser J, Geleziunas R, Robb ML, Kim JH, Michael NL, and Barouch DH*.  Rapid Establishment of the Viral Reservoir Prior to Systemic Viremia Following Mucosal SIV Infection of Rhesus Monkeys. In press, Nature 2014.