Stefani Spranger, PhD

Lab Info:

Principal Investigator: Stefani Spranger, PhD

Office/Location: MIT 76-453D

Phone: (617) 715-5882

Email: spranger@mit.edu

Category: Associate Members

Dr. Stefani Spranger is an Assistant Professor in the Department of Biology at MIT, a member of the Koch Institute for Integrative Cancer Research at MIT and an Associate Member of the Ragon Institute of MGH, MIT and Harvard.


The goal of the Spranger Lab is to understand the molecular mechanisms of a range of tumor cell-intrinsic, tissue-specific or environmental factors (e.g. infections) directly impacting the interaction between the cancer and the immune system. Understanding which permutations affect the anti-tumor immune response will answer thus far unanswered questions on the interplay between the immune system with the tumor and will facilitate the development of new rational therapeutic approaches. Specific project of the lab focus on tumor-resident DC populations, antigen-presentation and distribution of T cells between tumor and peripheral lymphoid organs.


Dr. Spranger is an Assistant Professor of Biology at MIT. She received her B.S./ M.S. from the Ludwig-Maximilians University in Munich and continued her doctoral work there under Professor Dolores J. Schendel at the Helmholtz-Zentrum Munich, Institute for Molecular Immunology, receiving her Ph.D. in 2011.  She completed her postdoctoral training at the University of Chicago in the laboratory of Professor Thomas F. Gajewski. During this period, she was supported by the German Research Foundation postdoctoral fellowship, the Irvington postdoctoral fellowship awarded by the Cancer Research Institute and a K99/R00 Transition to Independence award by the NCI. In 2017, she joined the Koch Institute for Integrative Cancer Research and the Department of Biology at MIT. She is a scholar of the Forbeck foundation and a Pew Stewart Scholar (2019).