Bryan Bryson, PhD

Lab Info:

Principal Investigator: Bryan Bryson, PhD

Office/Location: MIT 56-787A

Phone: 617-258-7641


Category: Members, Ragon Members

Dr. Bryan D. Bryson is an Assistant Professor in the Department of Biological Engineering at MIT and an Associate Member of the Ragon Institute of MGH, MIT and Harvard.


Dr. Bryson brings an engineering mindset to understanding the biology of tuberculosis (TB) infection and therapeutic response. His lab focuses in particular on macrophage phagosome function, using creative approaches to interrogate composition, mechanisms of pathogen control, and potential interventions to promote TB elimination by the phagosome. Dr. Bryson also investigates the mechanisms of TB control by kinase inhibitors, with the goal of defining signatures to serve as proxies for response; such response signatures may enable TB drug-discovery efforts in industry without the expertise or infrastructure required to work directly with the pathogen, accelerating therapeutic development. In addition, Dr. Bryson’s lab focuses on understanding and manipulating macrophage function broadly. Current work in this area includes identifying master regulators of the macrophage inflammatory state using systems-based approaches.


Dr. Bryson completed postdoctoral training at the Harvard T.H. Chan School of Public Health. He received a PhD in biological engineering and an undergraduate degree in mechanical engineering from MIT.