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Recent research and activities at Ragon

Germline-encoded affinity for cognate antigen enables vaccine-amplification of a human broadly neutralizing response against influenza virus

Sep 27

Germline-encoded affinity for cognate antigen enables vaccine-amplification of a human broadly neutralizing response against influenza virus

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Article originally published on Cell Press, Immunity, September 25, 2019 DOI:https://doi.org/10.1016/j.immuni.2019.09.001 Cambridge, MA. A team of researchers led by Dr. Daniel Lingwood from the Ragon Institute of MGH, MIT and Harvard have investigated how Human broadly neutralizing antibodies (bnAbs) against influenza virus can be biased for VHgene usage, suggesting gene-encoded development pathways. Sangesland et al. […]

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Identification Of A Direct Interaction Between NK Cells And A Subset Of HLA Class II Molecules

Aug 05

Identification Of A Direct Interaction Between NK Cells And A Subset Of HLA Class II Molecules

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News from the HPI Monday, 29. July 2019 Hamburg. A scientific team from the Research Department of Virus Immunology at the Heinrich Pette Institute, Leibniz Institute for Experimental Virology (HPI) has investigated the binding of NK cell receptors to HLA class II molecules. The results have now been published in the renowned journal “Nature Immunology”. […]

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Studies show early detection, prompt ARV treatment provide hope for the elimination of HIV

Jul 17

Studies show early detection, prompt ARV treatment provide hope for the elimination of HIV

Could early treatment with antiretroviral (ARV) therapy help the body fight off HIV? Researchers affiliated with the Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE) are convinced that early ARV therapy is critical to the treatment of HIV.   Researchers at the University of KwaZulu-Natal (UKZN) in Durban, South Africa are conducting studies they believe […]

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New vaccine strategy boosts T-cell therapy

Jul 11

New vaccine strategy boosts T-cell therapy

Super-charging a treatment for leukemia also makes it effective on solid tumors. Anne Trafton | MIT News Office A promising new way to treat some types of cancer is to program the patient’s own T cells to destroy the cancerous cells. This approach, termed CAR-T cell therapy, is now used to combat some types of […]

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The Ragon Institute announces the establishment of the Brunner Fund for Medical Discovery, Education and Social Good

Jul 02

The Ragon Institute announces the establishment of the Brunner Fund for Medical Discovery, Education and Social Good

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Ursula Brunner, a Swiss lawyer who has spent her career working for social and environmental justice, has just made a $5 million donation to the Ragon Institute to establish the Brunner Fund for Medical Discovery, Education and Social Good. This unique fund integrates medical research with social interventions that provide immediate benefit to the patients […]

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Eight Harvard students travel to KZN for a unique HIV research internship

Jul 01

Eight Harvard students travel to KZN for a unique HIV research internship

Some of the world’s brightest young health minds will be working under the supervision of senior HIV scientists to gain insight into combating this global epidemic. KWAZULU-NATAL, South Africa — Eight students from Harvard University are currently in KwaZulu-Natal (KZN) for an intensive internship program to learn about the important HIV prevention and cure research […]

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Ragon Institute top fundraiser for 34th annual AIDS Walk

Jun 18

Ragon Institute top fundraiser for 34th annual AIDS Walk

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Team Ragon raises $64,014 for crucial services BOSTON, Mass. – On Sunday, June 2nd, 2019, more than 30 Team Ragon members, including Ragon Institute employees and their friends and family, gathered at the DCR Hatch Memorial Shell for the annual Boston AIDS Walk and 5K Run. The AIDS Walk, now in its 34th year, is […]

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Breaking the Code: How is a mother’s immunity transferred to her baby?

Jun 13

Breaking the Code: How is a mother’s immunity transferred to her baby?

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Ragon Institute-led study identifies factors contributing to placental transfer of antibodies CAMBRIDGE, Mass. – One of the most successful interventions in reducing infectious disease worldwide, vaccination still has limited effectiveness in protecting one group of patients – newborn infants. Now a study based at the Ragon Institute of MGH, MIT and Harvard has determined how […]

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Ragon Institute hosts Neuro-Immune Symposium

May 28

Ragon Institute hosts Neuro-Immune Symposium

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Two-day symposium brings together experts in the growing field of neuroimmunology On March 28th and 29th, 2019, the Ragon Institute of MGH, MIT and Harvard hosted a Neuro-Immune Symposium with the goal of bringing together world-class experts in neuroimmunology and the related fields of neurobiology and immunology to share their cutting-edge research and discoveries, and […]

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Early antiretroviral treatment may preserve key immune responses to HIV

May 22

Early antiretroviral treatment may preserve key immune responses to HIV

Ragon Institute study findings could pave the way to vaccine development CAMBRIDGE, Mass. – Instituting combination antiretroviral (ART) treatment at the earliest stages of HIV infection may allow the generation of functional CD8 “killer” T cells and preservation of the CD4 helper T cells that are the virus’s primary target.  Investigators from the Ragon Institute […]

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New immune markers of exposure to Mycobacterium tuberculosis challenge decades of clinical practice

May 20

New immune markers of exposure to Mycobacterium tuberculosis challenge decades of clinical practice

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Tuberculosis (TB) is the leading infectious cause of death worldwide, and is caused by the slow growing bacterium Mycobacterium tuberculosis (Mtb). Because the time between infection and disease can be long – years or even decades – a major challenge for public health is knowing who is at risk for becoming ill so that they […]

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5 South African Traditional Healers honored in the USA

May 16

5 South African Traditional Healers honored in the USA

Five Traditional Healers from KwaZulu-Natal – who are central to an innovative program run in partnership with a local South African NGO and the KZN Department of Health – traveled to Cambridge, Massachusetts, where they were hosted for five days and honored for their work by the prestigious Ragon Institute of MGH, MIT and Harvard. […]

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Ragon Institute study identifies viral peptides critical to natural HIV control

May 02

Ragon Institute study identifies viral peptides critical to natural HIV control

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T-cell targeting of essential amino acids may underlie spontaneous HIV suppression, define path to a vaccine CAMBRIDGE, Mass. – Investigators at the Ragon Institute of MGH, MIT and Harvard have used a novel approach to identify specific amino acids in the protein structure of HIV that appear critical to the ability of the virus to […]

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MGH receives $200 million to advance research into complex diseases

May 02

MGH receives $200 million to advance research into complex diseases

Largest gift in hospital history will bolster the Ragon Institute of MGH, MIT and Harvard BOSTON – Massachusetts General Hospital (MGH) announced it has received the largest gift in the hospital’s history – $200 million – to endow the Ragon Institute of MGH, MIT and Harvard. This landmark contribution from philanthropists and longtime hospital supporters […]

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Announcement of Record Gift to MGH to Endow the Ragon Institute

Apr 26

Announcement of Record Gift to MGH to Endow the Ragon Institute

We are thrilled to let you know that the MGH has received the largest philanthropic gift in its history – a $200 million contribution to support the Ragon Institute of MGH, MIT and Harvard. This extraordinary gift comes from Phillip (Terry) and Susan Ragon, long-time supporters of the hospital, whose transformational contribution will ensure that […]

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