Category Archives: research

Towards ‘universal’ protection: designing the next-generation influenza vaccine

Oct 21

Towards ‘universal’ protection: designing the next-generation influenza vaccine

Scientists from the Ragon Institute of MGH, MIT and Harvard, led by Dr. Aaron Schmidt, Assistant Professor of Microbiology, have partnered with the Duke Human Vaccine Institute (DHVI) on a nation-wide, multidisciplinary program to develop a more universally protective influenza vaccine.   The Collaborative Influenza Vaccine Innovation Centers (CIVICs) program, driven and supported by the […]

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A shot in the arm for vaccine research

Oct 04

A shot in the arm for vaccine research

Ragon Institute harnesses new knowledge about HIV to reinvent immunology   Mary Todd Bergman | Harvard Correspondent   Originally posted on The Harvard Gazette, September 19, 2019   With a promising HIV vaccine already in clinical trials, and research revealing how some people can naturally control HIV without medications, the Ragon Institute of MGH, MIT, […]

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Germline-encoded affinity for cognate antigen enables vaccine-amplification of a human broadly neutralizing response against influenza virus

Sep 27

Germline-encoded affinity for cognate antigen enables vaccine-amplification of a human broadly neutralizing response against influenza virus

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Article originally published on Cell Press, Immunity, September 25, 2019 DOI:https://doi.org/10.1016/j.immuni.2019.09.001 Cambridge, MA. A team of researchers led by Dr. Daniel Lingwood from the Ragon Institute of MGH, MIT and Harvard have investigated how Human broadly neutralizing antibodies (bnAbs) against influenza virus can be biased for VHgene usage, suggesting gene-encoded development pathways. Sangesland et al. […]

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Identification Of A Direct Interaction Between NK Cells And A Subset Of HLA Class II Molecules

Aug 05

Identification Of A Direct Interaction Between NK Cells And A Subset Of HLA Class II Molecules

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News from the HPI Monday, 29. July 2019 Hamburg. A scientific team from the Research Department of Virus Immunology at the Heinrich Pette Institute, Leibniz Institute for Experimental Virology (HPI) has investigated the binding of NK cell receptors to HLA class II molecules. The results have now been published in the renowned journal “Nature Immunology”. […]

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Studies show early detection, prompt ARV treatment provide hope for the elimination of HIV

Jul 17

Studies show early detection, prompt ARV treatment provide hope for the elimination of HIV

Could early treatment with antiretroviral (ARV) therapy help the body fight off HIV? Researchers affiliated with the Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE) are convinced that early ARV therapy is critical to the treatment of HIV.   Researchers at the University of KwaZulu-Natal (UKZN) in Durban, South Africa are conducting studies they believe […]

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New vaccine strategy boosts T-cell therapy

Jul 11

New vaccine strategy boosts T-cell therapy

Super-charging a treatment for leukemia also makes it effective on solid tumors. Anne Trafton | MIT News Office A promising new way to treat some types of cancer is to program the patient’s own T cells to destroy the cancerous cells. This approach, termed CAR-T cell therapy, is now used to combat some types of […]

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Breaking the Code: How is a mother’s immunity transferred to her baby?

Jun 13

Breaking the Code: How is a mother’s immunity transferred to her baby?

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Ragon Institute-led study identifies factors contributing to placental transfer of antibodies CAMBRIDGE, Mass. – One of the most successful interventions in reducing infectious disease worldwide, vaccination still has limited effectiveness in protecting one group of patients – newborn infants. Now a study based at the Ragon Institute of MGH, MIT and Harvard has determined how […]

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Early antiretroviral treatment may preserve key immune responses to HIV

May 22

Early antiretroviral treatment may preserve key immune responses to HIV

Ragon Institute study findings could pave the way to vaccine development CAMBRIDGE, Mass. – Instituting combination antiretroviral (ART) treatment at the earliest stages of HIV infection may allow the generation of functional CD8 “killer” T cells and preservation of the CD4 helper T cells that are the virus’s primary target.  Investigators from the Ragon Institute […]

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New immune markers of exposure to Mycobacterium tuberculosis challenge decades of clinical practice

May 20

New immune markers of exposure to Mycobacterium tuberculosis challenge decades of clinical practice

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Tuberculosis (TB) is the leading infectious cause of death worldwide, and is caused by the slow growing bacterium Mycobacterium tuberculosis (Mtb). Because the time between infection and disease can be long – years or even decades – a major challenge for public health is knowing who is at risk for becoming ill so that they […]

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Ragon Institute study identifies viral peptides critical to natural HIV control

May 02

Ragon Institute study identifies viral peptides critical to natural HIV control

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T-cell targeting of essential amino acids may underlie spontaneous HIV suppression, define path to a vaccine CAMBRIDGE, Mass. – Investigators at the Ragon Institute of MGH, MIT and Harvard have used a novel approach to identify specific amino acids in the protein structure of HIV that appear critical to the ability of the virus to […]

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