Category Archives: research

New MIT Class: “COVID-19, SARS-CoV-2, and the Pandemic”

Sep 21

New MIT Class: “COVID-19, SARS-CoV-2, and the Pandemic”

  • posted by Ragon Institute
  • in research
  • Comments Off on New MIT Class: “COVID-19, SARS-CoV-2, and the Pandemic” Comments

Ragon Institute Associate Director Facundo Batista and MIT Professor Richard Young create new MIT Biology public access COVID-19 course.   Image courtesy of MIT Biology and NIAID/Wikimedia Commons   With COVID-19 sweeping the nation and the world, biomedical science simultaneously paused and accelerated in unprecedented ways. Many labs were required to shut down during the […]

Read more
Engineered to Fight: Dual CAR T cells show promise against HIV

Aug 31

Engineered to Fight: Dual CAR T cells show promise against HIV

  • posted by Ragon Institute
  • in research
  • Comments Off on Engineered to Fight: Dual CAR T cells show promise against HIV Comments

Researchers from the Ragon Institute of MGH, MIT and Harvard and the Perelman School of Medicine at the University of Pennsylvania developed a new Dual CAR T cell immunotherapy that combats HIV infection in humanized mice. Image: HIV infecting a human cell, courtesy of NIH Image library A recent study published in the journal Nature […]

Read more
Single Gene, Broad Response

Aug 27

Single Gene, Broad Response

Single VH Gene Allows for Broad-Spectrum Antibody Response to LPS   Image: Immunoglobulin heavy chain variable domain, VH   Daniel Lingwood, PhD, Ragon Group Leader, recently published a paper in Cell Reports entitled, “A single human VH gene allows for a broad-spectrum antibody response targeting 2 bacterial lipopolysaccharides in the blood.” This paper, whose lead […]

Read more
Blocked and Locked:  Unique HIV Reservoirs in Elite Controllers

Aug 26

Blocked and Locked: Unique HIV Reservoirs in Elite Controllers

  • posted by Ragon Institute
  • in research
  • Comments Off on Blocked and Locked: Unique HIV Reservoirs in Elite Controllers Comments

Ragon Institute researchers show elite controllers have HIV viral reservoirs in gene deserts which may help prevent viral rebound and contribute to natural control of HIV.   

Read more
Losing the Center: COVID-19 Cytokine Storms May Prevent a Durable Immune Response

Aug 19

Losing the Center: COVID-19 Cytokine Storms May Prevent a Durable Immune Response

  • posted by Ragon Institute
  • in research
  • Comments Off on Losing the Center: COVID-19 Cytokine Storms May Prevent a Durable Immune Response Comments

Image: Germinal centers in a lymph node, courtesy of Shiv Pillai Lack of germinal centers in COVID-19 immune response may prevent patients from developing long-lasting immunity to the SARS-CoV-2 virus Shiv Pillai, MD, Ph.D, Member of the Ragon Institute of MGH, MIT and Harvard and professor at Harvard Medical School, recently published a paper in […]

Read more
Seeing the Forest For the Trees:   Predictive Immune Markers in COVID-19 Response

Aug 06

Seeing the Forest For the Trees:

Predictive Immune Markers in COVID-19 Response

  • posted by Ragon Institute
  • in research
  • Comments Off on Seeing the Forest For the Trees:

    Predictive Immune Markers in COVID-19 Response
    Comments

Results of partnership between the Ragon Institute of MGH, MIT and Harvard and UW Medicine identify five markers of the humoral immune response that may be able to predict COVID-19 patient outcomes.   A recent study published in Immunity identifies five immune response markers which, collectively, were able to correctly classify both convalescent COVID-19 patients […]

Read more
Single-shot COVID-19 vaccine protects non-human primates

Jul 30

Single-shot COVID-19 vaccine protects non-human primates

  • posted by Ragon Institute
  • in research
  • Comments Off on Single-shot COVID-19 vaccine protects non-human primates Comments

by: Beth Israel Deaconess Medical Center   Findings lay groundwork for clinical development program     Boston, Mass. – The development of a safe and effective vaccine will likely be required to end the COVID-19 pandemic. A group of scientists, led by Beth Israel Deaconess Medical Center (BIDMC) immunologist Dan H. Barouch, MD, PhD, now report […]

Read more
It Takes Two: Immune Correlates of Protection in RTS,S/AS01 Malaria Vaccine

Jul 22

It Takes Two: Immune Correlates of Protection in RTS,S/AS01 Malaria Vaccine

  • posted by Ragon Institute
  • in research
  • Comments Off on It Takes Two: Immune Correlates of Protection in RTS,S/AS01 Malaria Vaccine Comments

Image: Immune cells in malaria patient. Credit: National Institute of Neurological Disorders and Stroke, NIH   Researchers at the Ragon Institute of MGH, MIT and Harvard, in collaboration with the global health non-profit PATH and pharmaceutical company GSK, have discovered two markers of immunity in response to the RTS,S/ASO1 malaria vaccine that correlated strongly with […]

Read more
Kneel-In Vigil: In Support and Solidarity

Jun 04

Kneel-In Vigil: In Support and Solidarity

We want to express our deep sadness over the recent and violent deaths of George Floyd, Ahmaud Arbery and Breonna Taylor in the US—three of the latest victims of the systemic racism that continues to plague our society. The last week has brought into crisp focus the deep racism that remains pervasive throughout our country, […]

Read more
Gathering Critical Clues

Jun 04

Gathering Critical Clues

To understand how any given disease affects the body, scientists need a wide array of tools. One of the most valuable and indispensable instruments in their toolkit are clinical samples—small amounts of blood, urine, mucus, spit, and tissue that can be used to study a disease in a patient.  For COVID-19, a disease that has an […]

Read more