Reeves

R. Keith Reeves, Ph.D.

Lab Info:

Principal Investigator: R. Keith Reeves, Ph.D.

Office/Location: CLS Rm 1037

Phone: (617) 735-4586

Email: rreeves@bidmc.harvard.edu

Category: Associate Members

Dr. R. Keith Reeves received his Ph.D. in Microbiology from the University of Alabama at Birmingham followed by postdoctoral training at the New England Primate Research Center of Harvard Medical School. His postdoctoral training focused on the role of innate immune responses in modulating SIV transmission and pathogenesis, as well as the efficacy of live attenuated SIV vaccines. He is currently an Associate Professor of Medicine and Director of the Advanced Technologies Core at the Center for Virology and Vaccine Research at BIDMC.

 

His laboratory focuses primarily on the role(s) of natural killer (NK) in modulating HIV and SIV disease, as well as other viruses such as HCV and CMV. His laboratory has identified novel subpopulations of mucosal NK cells, and was the first to identify evidence of NK cell memory in any primate species. Current projects are investigating how these adaptive memory NK cell responses can be harnessed in the context of HIV vaccines and cure strategies.

 

SELECTED PUBLICATIONS

Reeves, R. K., Evans, T. I., Gillis, J., Wong, F. E., Kang, G., Li, Q., and Johnson, R. P. 2012. SIV infection induces increased trafficking of plasmacytoid dendritic cells to the gut mucosa. J. Infect. Dis. 206(9):1462-1468.

 

Li, H., Evans, T. I., Gillis, J., Estes, J.D., Keele, B.F., Klatt, N.R., and Reeves, R. K. 2014. Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection. PLoS Path. 10(12):e1004551.

 

Reeves, R. K., Li, H., Jost, S., Blass, E., Li, H., Eslamizar, L., Altfeld, M., von Andrian, U. H., and Barouch, D. H. 2015. Antigen-specific NK cell memory in rhesus macaques. Nat. Immunol. 16(9):927-932.