Filippos Porichis, PhD.
Principal Investigator: Filippos Porichis, PhD.
Office/Location: 400TS 856
Phone: (857) 268-7032
Dr. Porichis’s research focus is on T cell responses in HIV infection, with the goal of understanding the etiology of T cell dysfunction and the identification of novel ways of manipulating immunoregulatory pathways to enhance immunity to HIV.Over the past 5 years, he has investigated the inhibitory impact of regulatory pathways like PD-1 and IL-10 and has shown that modulation of these inhibitory pathways can restore effective HIV-specific CD4 and CD8 T cell functionality.
His current projects include the identification of the transcriptional signatures of HIV-specific CD4 T cell responses and the investigation of the fine structure and regulation of HIV-specific CD4 T cell responses, including follicular T helper cells, in the setting of the recently funded, multicenter CHAVI-ID grant.
Through collaborations with the affiliated institutes KRITH and HPP in Durban, South Africa, Dr. Porichis also studies the intracellular regulators of HIV and MTB specific CD4 T cell function in HIV/MTB co-infection.
Finally, Dr. Porichis is interested in the development of novel techniques that will enable greater functional characterization of effective immune responses. He participated in the development of next-generation fluorescent in situ hybridization (FISH) assays in collaboration with Affymatrix, which allow for the sensitive detection of RNA molecules by flow cytometry. He is also actively involved in the creation of panels forCyTOF (mass cytometry) for the characterization of T cell responses in HIV infection.
Dr. Filippos Porichis is the Director of International Programs at the Ragon Institute and serves as a member of the Executive Committee of the MGH Center for Global Health. He is an Instructor in Medicine at Harvard Medical School and an Assistant in Immunology at Massachusetts General Hospital. He received his PhD from the University of Crete and the Institute of Molecular Biology and Biotechnology in Crete and subsequently joined the Ragon Institute for his Post-Doctoral training under the supervision of Dr. Daniel Kaufmann.
Muska Hassan | MHASSAN5@mgh.harvard.edu
Muska is a research technician in the Porichis Lab. She graduated from UMass Amherst as Biology major in May 2013. She started her first research experience through the National Cancer Institute at the Broad Institute of MIT and Harvard where she researched on the MAP-kinase pathway in BRAFV600E mutant melanoma cell lines. Muska enjoys photography, exploring different coffee shops in the Boston area, cooking, going for a nice run around the Charles River, and watching wedding videos on YouTube.
Alexandra Massa | email@example.com
Alexandra joined the Porichis lab as a research technician in October 2014. She received her B.S. in Neuroscience and B.A. in Chemistry from Stonehill College. As an undergraduate, Alexandra completed her thesis work in Craig Garner’s lab at Stanford University which focused on the etiology of α-synuclein aggregation in Parkinson’s disease. She has also published clinical research with Massachusetts General Hospital and Harvard Medical School examining bone density in individuals with autism. In addition to her research, Alexandra has participated in the Miss Pennsylvania USA pageant and remains passionate about health and fitness. She enjoys watching HGTV and spending time with her ‘well-fed’ cat, Moo!
Adrienne Yanez | firstname.lastname@example.org
Adrienne joined the Porichis lab as a research fellow in March 2015. She is working to identify and manipulate gene regulatory networks that improve HIV-specific CD4 T-cell responses to HIV infection. She received her Ph.D. from Harvard University, where she studied global regulation of miRNA activity by translation initiation factors in melanoma. In her spare time, she enjoys playing outside, exploring her surroundings, and gazing into empty centrifuges (see picture above).