NEWS

Recent research and activities at Ragon

Ragon Institute Members Receive Funding from MassCPR for COVID-19 Projects

As part of its COVID-19 response, the Ragon Institute is working within the Massachusetts Consortium for Pathogen Readiness, a multi-institutional initiative convened by Harvard Medical School and the Ragon Institute, to combat the disease and to prepare for future outbreaks. Ragon Institute director, Bruce Walker, MD, serves as co-director and founding member, and many of […]

Read more
The Ragon Institute: Harnessing the Immune System to Combat COVID-19

Image: Scanning electron microscope image of SARS-CoV-2 virus emerging from cells. Image courtesy of NIAID   Cambridge, MA, April 22, 2020: The Ragon Institute of MGH, MIT and Harvard, a world leader in human immunology and infectious diseases, is leading efforts to understand and combat the SARS-CoV-2 virus, the cause of the global COVID-19 pandemic. […]

Read more
The Ragon Institute of MGH, MIT and Harvard Receives Gift from Nancy Zimmerman to Help Fund Development of Early Response COVID-19 Diagnostic

Boston, March 30, 2020 – The Ragon Institute of MGH, MIT and Harvard today announced it has received a gift from Nancy Zimmerman to help fund development of an early response coronavirus (COVID-19) diagnostic that would support medical and other front-line professionals and help manage the current pandemic. Specifically, the funding from Ms. Zimmerman, who […]

Read more
Understanding the Score: A Dynamic Interrogation of Acute HIV Infection

Alex Shalek, Ragon associate member, has a new study published today in Nature Medicine, Integrated Single-Cell Analysis of Multicellular Immune Dynamics during Hyper-Acute HIV-1 Infection. This study uses single-cell RNA sequencing to understand immune system dynamics after acute HIV infection, with samples provided from the FRESH (Females Rising through Education, Support, and Health) study in […]

Read more
New Coronavirus Initiative

Mar 02

The Ragon Institute, with its commitment to interdisciplinary collaboration and patient-focused research, has begun a multipronged approach towards understanding, treating, and preventing infections with the new human coronavirus SARS-CoV-2. Ragon Institute scientists are playing  a leadership role in mobilizing an unprecedented Boston-Cambridge consortium dedicated to collaborative efforts to ending the growing pandemic, bringing together Harvard, […]

Read more
Alum for the Ride

Feb 21

  Alum for the Ride   Darrell Irvine, PhD, Ragon Steering Committee Member and MIT Professor of Materials Science and Biological Engineering, has just published a paper in Nature Medicine showing a way to engineer an increased immune response to the vaccine adjuvant aluminum hydroxide, also known as alum, in an HIV vaccine given to […]

Read more
Flu Vaccines: Best Supporting Actor?

Galit Alter has published a new study in the Journal of Clinical Investigation entitled “Selective induction of antibody effector functional responses using MF59-adjuvanted vaccination.” This study is taking a new approach to determining flu vaccine efficacy, examining not the antigen, a piece of flu virus that is the main component of the vaccine, but the supporting […]

Read more
Machine Learning: the Right Tool for the Right Diagnostic Test

Ragon faculty member Musie Ghebremichael, PhD, recently published a BMC paper entitled “A comparison of machine learning techniques for classification of HIV patients with antiretroviral therapy-induced mitochondrial toxicity from those without mitochondrial toxicity.” Additional authors include Jong Lee, Elijah Paintsil, and Vivek Gopalakrishnan, of University of Massachusetts, Lowell; Yale University; and The Johns Hopkins University, […]

Read more
Into the Spotlight: Towards a Drug-Free Remission

The Ragon Institute of MGH, MIT and Harvard received $10 million from the Bill & Melinda Gates Foundation to move towards drug-free HIV remission.      HIV  HIV remains a major global health challenge, with UNAIDS reporting 37.9 million people living with HIV and 1.7 million new cases each year. Antiretroviral therapy (ART) allows people […]

Read more
Transformative Approaches to a TB Vaccine

New research center will help advance TB vaccine development For centuries tuberculosis (TB) has been a major global health problem and the world’s leading infectious killer.  To combat this deadly disease, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), recently announced new contract awards to establish […]

Read more
Groundbreaking HIV vaccine design strategy shows promise in proof-of-principle tests

A new approach that targets young immune cells may also work for creating vaccines against the flu, dengue, malaria and hepatitis C October 31, 2019 LA JOLLA, CA A collaborative team of scientists has made a successful proof-of-principle demonstration of an advanced HIV vaccine strategy—an approach that may also work in protecting people from an […]

Read more
Towards ‘universal’ protection: designing the next-generation influenza vaccine

Scientists from the Ragon Institute of MGH, MIT and Harvard, led by Dr. Aaron Schmidt, Assistant Professor of Microbiology, have partnered with the Duke Human Vaccine Institute (DHVI) on a nation-wide, multidisciplinary program to develop a more universally protective influenza vaccine.   The Collaborative Influenza Vaccine Innovation Centers (CIVICs) program, driven and supported by the […]

Read more
A shot in the arm for vaccine research

Ragon Institute harnesses new knowledge about HIV to reinvent immunology   Mary Todd Bergman | Harvard Correspondent   Originally posted on The Harvard Gazette, September 19, 2019   With a promising HIV vaccine already in clinical trials, and research revealing how some people can naturally control HIV without medications, the Ragon Institute of MGH, MIT, […]

Read more
Germline-encoded affinity for cognate antigen enables vaccine-amplification of a human broadly neutralizing response against influenza virus

Article originally published on Cell Press, Immunity, September 25, 2019 DOI:https://doi.org/10.1016/j.immuni.2019.09.001 Cambridge, MA. A team of researchers led by Dr. Daniel Lingwood from the Ragon Institute of MGH, MIT and Harvard have investigated how Human broadly neutralizing antibodies (bnAbs) against influenza virus can be biased for VHgene usage, suggesting gene-encoded development pathways. Sangesland et al. […]

Read more
Identification Of A Direct Interaction Between NK Cells And A Subset Of HLA Class II Molecules

News from the HPI Monday, 29. July 2019 Hamburg. A scientific team from the Research Department of Virus Immunology at the Heinrich Pette Institute, Leibniz Institute for Experimental Virology (HPI) has investigated the binding of NK cell receptors to HLA class II molecules. The results have now been published in the renowned journal “Nature Immunology”. […]

Read more