Past Funded Awards

Mechanism: Innovation
Title: Linking NK antiviral function to Genome-wide Analysis Screens
Investigators: De Jager (BWH), Galit Alter (MGH)

Mechanism: Innovation
Title: Generation, escape, and effects of strain specific antibody responses
Investigators: Manish Sagar (BWH), Galit Alter (MGH)

Mechanism: Innovation
Title: Innate Host Genetic Determinants that Restrict Mother to Child HIV-1 Clade C Transmission
Investigators: William Carr (MGH), Thumbi Ndungu (UKZN)

Mechanism: Innovation
Title: A novel approach to generate neutralizing antibodies against HIV
Investigators: Shiv Pillai (MGH), Galit Alter (MGH)

Mechanism: Innovation
Title: Role of the Tim-3/Galectin-9 Pathway in HIV-1 immunopathogenesis
Investigators: Marylyn Addo (MGH), Mary Carrington (MGH)

Mechanism: Innovation
Title: Identification of genes uniquely expressed in subsets of murine memory NK cells
Investigators: Ulrich von Andrian (HMS), Marcus Altfeld (MGH)

Mechanism: Innovation
Title: Molecular mechanism of TIM-3 in T cell exhaustion
Investigators: Vijay Kuchroo (HMS), Laurie Glimcher (HSPH)

Mechanism: Innovation
Title: High-resolution three-dimensional structure reconstruction of the unliganded HIV-1 envelope glycoprotein trimer from cryo-electron micrographs
Investigators: Joseph Sodroski (DFCI), Dennis Burton (Scripps)

Mechanism: Innovation
Title: gp120 Immunogen Engineering by Yeast Surface Display
Investigators: Dane Wittrup (MIT), Dennis Burton (Scripps)

Mechanism: Fellowship
Title: Understanding the role of NK cell mediated anti-viral memory responses
Investigators: Ulrich von Andrian (HMS), Silke Paust (Fellow, HMS), Ragon co-mentor: Marcus Altfeld (MGH)

Mechanism: Fellowship
Title: High-throughput immune repertoire characterization of HIV progressors and elite controllers
Investigators: George Church (HMS), Francois Vigneault (Fellow, HMS), Ragon co-mentor: Xu Yu (MGH)

Mechanism: Pilot
Title: Role of HIV-1 Encoded Peptides in Modulating Innate Immune Recognition by HLA-C Restricted Killer Immunoglobulin-like Receptors
Investigator: William Carr (MGH/UKZN)

Mechanism: Targeted initiative
Title: Impact of antigen formulation on protective efficacy against SIV
Investigator: Dan Barouch (BIDMC)

Mechanism: Platform award
Title: Ragon Humanized Mouse Platform
Investigators: Andrew Tager (MGH), Andrew Luster (MGH), Jianzhu Chen (MIT)

Mechanism: Innovation Award
Title: Development of a time-lapse videomicroscopy assay to measure the kinetics of CTL recognition and cytolysis of HIV infected target cells
Investigators: Darrell Irvine (MIT), Bruce Walker (MGH), Mark Brockman (MGH)

Mechanism: Innovation Award
Title: Contribution of precursor frequencies of naïve CD8+ T cells to the immunodominance patterns of HIV-1 specific CD8+ T cell responses in Acute HIV-1 infection
Investigators: J. Christopher Love (MIT), Marcus Altfeld (MGH)

Mechanism: Innovation Award
Title: Impact of HLA on NK Cell Receptor Trafficking into the Immunological Synapse
Investigators: Darrell Irvine (MIT), Galit Alter (MGH)

Mechanism: Innovation Award
Title: Mechanistic Origin of the Ability of Individuals with Particular HLA Alleles to Control HIV Viral Load
Investigators: Arup K. Chakraborty (MIT), Todd Allen (MGH), Marcus Altfeld (MGH), Bruce Walker (MGH)

Mechanism: Innovation Award
Title: Antigenic Potential of HIV Antigens Delivered and Processed through Distinct Intracellular Pathways
Investigators: Darrell Irvine (MIT), Sylvie Legall (MGH)

Mechanism: Innovation Award
Title: Synthetic mRNA-loaded nanoparticles for vectorless vaccine delivery
Investigators: Darrell Irvine (MIT), Daniel Kavanagh (MGH)

Mechanism: Innovation Award
Title: HIV Inhibition: Development of a Novel High Throughput Single Cell Array to Define Correlates of Antiviral Cytoxic T-lymphocyte (CTL) Function
Investigators: J. Christopher Love (MIT), Bruce Walker (MGH)

Mechanism: Innovation Award
Title: Understanding NK Cell Biology at the Single Cell Level
Investigators: J. Christopher Love (MIT), Galit Alter (MGH)

Mechanism: Innovation Award
Title: Generation of anti-HLA-restricted-TCR-like monoclonal antibodies by micrograving for the specific recognition, visualization and analysis of HIV-1
Investigators: J. Christopher Love (MIT), Xu Yu (MGH), Mathias Litcherfeld (MGH)

Mechanism: Innovation Award
Title: Ultra-Deep Sequencing of HIV
Investigators: Todd Allen, Matthew Henn (MIT), Thumbi Ndung'd (HPP)