Category Archives: research

Clinical Research Coordinators Volunteer at the Celebration of Life

At the Ragon Institute, the communities and individuals affected by HIV and AIDS are the driving force behind the science. While much of our work focuses on the epicenter of the epidemic in Durban, South Africa, we know the importance of engaging communities in Boston as well. On Tuesday, November 20th, 2018 a team of […]

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FRESH program combines basic science with social benefits for women at risk of HIV

Ragon Institute initiative addresses socioeconomic factors affecting HIV risk in young women in South Africa Sue McGreevey | Massachusetts General Hospital   A program established by investigators from the Ragon Institute of Massachusetts General Hospital (MGH), MIT and Harvard is addressing the persistently elevated risk of HIV infection among young women in South Africa from […]

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Novel insights into antibody protection mechanisms mark a step forward in the search for an HIV vaccine

Vivian Chou | Harvard University   The search for a safe and effective HIV vaccine is a major scientific and clinical challenge. In an exciting new Nature Medicine paper published earlier this week, researchers at the Ragon Institute and their collaborators uncover important insights into how antibodies provide protection following vaccination. These findings bring researchers […]

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Ebola virus experts discover a powerful approach for stopping outbreaks

Bronwyn Gunn and Galit Alter | Ragon Institute of MGH, MIT and Harvard   From 2013–2016, West Africa faced the deadliest Ebola outbreak the world has ever seen. By the time the outbreak was declared over, 11,325 people had died. Antibody therapy is considered among the most promising treatments for the Ebola virus infection, and […]

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Study: Cellular changes lead to chronic allergic inflammation in the sinus

Findings suggest mechanisms for the persistence of nasal polyps and possible new treatment strategies. Anne Trafton | MIT News Office   Chronic rhinosinusitis is distinct from your average case of seasonal allergies. It causes the sinuses to become inflamed and swollen for months to years at a time, leading to difficulty breathing and other symptoms […]

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New Evidence for the Role of PKCβ in B Cell Fate Decision

Vivian Chou | Harvard University   The immune system plays the crucial role of defending the body against pathogens that can cause dangerous and deadly infections. How the immune system performs this incredible function has spurred numerous research questions, many still unanswered. In a recent study published in Immunity, researchers at the Ragon Institute in […]

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Ragon Institute Hosts Cellular Immunity Workshop

On January 4th and 5th, 2018, leading researchers in the field of cellular immunology participated in an interactive workshop entitled “Prospects for designing and testing vaccines to elicit cellular immunity against HIV”, hosted by the Ragon Institute of MGH, MIT, and Harvard.   The meeting focused on how cell-mediated immunity can be incorporated into the […]

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New Insights into the Early Immune Response against Viral Infection

Vivian Chou | Harvard Medical School In a recent report in Cell, researchers at the Ragon Institute in Cambridge, MA and their collaborators announced a groundbreaking new model of how immunity is initiated in response to viral infections. Achieving broad and long-lasting protection against viruses such as influenza, HIV, and Zika has been a longstanding […]

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Clinical Efficacy Trial of Ragon Institute-Supported HIV Vaccine Underway in Africa

“Mosaic” vaccine designed to respond to many viral strains, address challenge of genetic diversity. Sue McGreevey | Massachusetts General Hospital A phase 2b clinical trial of a novel preventive HIV vaccine regimen developed by researchers at the Ragon Institute of Massachusetts General Hospital (MGH), MIT and Harvard, Beth Israel Deaconess Medical Center (BIDMC), and partners has […]

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Researchers Develop New Method to Generate Human Antibodies

An international team of scientists has developed a method to rapidly produce specific human antibodies in the laboratory. The technique, which will be described in a paper to be published July 24, 2017 in The Journal of Experimental Medicine, could speed the production of antibodies to treat a wide range of diseases and facilitate the […]

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