Ragon Institute

Harnessing the Immune System to Prevent and Cure Human Disease

The Ragon Institute of Mass General Brigham, MIT, and Harvard brings together scientists, clinicians, and engineers from distinct fields to harness the potential of the immune system to prevent and cure human diseases.

Ragon Impact

Ragon researchers have made huge strides towards a working HIV vaccine - and an end to a decades-long epidemic.
Our efforts in South Africa have made a real change for thousands of people in the most vulnerable areas of the country.
From HIV to TB to COVID-19 and beyond — since our founding in 2009 our focus has expanded to cover more areas of immunology, as we develop research with the potential to improve the lives of millions globally.

Recent Developments

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Bryson Lab Study Defines TB Vaccine Targets Directly From Infected Human Cells and Shows How to Deliver Them With mRNA

Nov 6, 2025 Features

A new study led by the Bryson Lab at the Ragon Institute and published in Science Translational Medicine lays out a practical roadmap for making better tuberculosis (TB) vaccines by starting from what infected human immune cells actually show to CD4 T cells. The team used a technique called immunopeptidomics to see which TB proteins infected human immune […]

Collaborate. Research. Cure.

These three words embody the spirit of what we represent at the Ragon Institute of Mass General Brigham, MIT, and Harvard. Our approach draws on the wealth of cross-disciplinary knowledge created by our collaborative approach — understanding that progress comes not from silos of expertise, but from working together across scientific fields. The three thematic programs of the Ragon Institute focus our work into distinct yet overlapping areas that move the field of immunology forward.

Program for Immunophysiology and Disease

Revealing mechanisms of immune control and disease pathogenesis to prepare for, and protect against, global health threats.

Program for Patient Focused Immunology

Bringing observations from the bedside to the bench and back, worldwide.

Program for Immune Engineering

Leveraging discoveries to develop cutting-edge diagnostics and treatments.

Our Labs

The Ragon Institute brings together researchers from across Mass General Brigham, MIT, and Harvard whose expertise ranges from developing new tools to studying cell interactions to identifying potential cures for the HIV epidemic. Our faculty includes our Core Members, who are primarily located at the Ragon. Alongside them are our Associate Members, frequent collaborators whose work is done at another institute, and Steering Committee Members, collaborators who also provide high-level scientific guidance to the Ragon.

Ragon International

Our commitment to immunology and research extends beyond our home in Cambridge. Global health is a pillar of our research and outreach, and the Ragon International programs reflect our longstanding commitment to health equity around the world. Our South African programs include FRESH and ITEACH — with more to come in future. Each combines basic science with social good in the places that need it most.

Education & Outreach

The Office of Education and Outreach supports the Institute’s mission by offering programs such as RISE and PRISM to students from the Greater Boston community, setting a foundation for the next generation of researchers.

Support Our Vital Research

As a non-profit institution, the Ragon Institute relies on the generosity of our donors to advance our world-changing research. Your support provides our faculty and postdoctoral researchers with the flexibility to pursue promising avenues for treatments and cures for some of the 21st century’s most pressing health challenges. Whether giving to labs at the Ragon, outreach programs in the Boston area, or research programs in South Africa, you make a positive impact on what we do.

Ragon Culture

Our people are our greatest asset. We are committed to creating a supportive and inclusive environment that is welcoming for all. Our Employee Resource Groups provide a space for anyone to find their community, while our Culture Committee spearheads Institute-wide celebrations to bring us all together. Research is at the heart of what we do — but it’s not the only thing we do.

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Ragon Culture

Our people are our greatest asset. We are committed to creating a supportive and inclusive environment that is welcoming for all. Our Employee Resource Groups provide a space for anyone to find their community, while our Culture Committee spearheads Institute-wide celebrations to bring us all together. Research is at the heart of what we do — but it’s not the only thing we do.

Learn More

Join Our Team

Whether you are an early-career researcher looking for the next step in your career, a physician-scientist with decades of experience, or a seasoned administrative professional, the Ragon is committed to fostering a unique and welcoming work environment for all employees.

Our New Home

Our new building supports the Institute’s research to harness the power of the human immune system to prevent and cure disease. The 323,000 square-foot space, located in the heart of Kendall Square at 600 Main Street, includes lab and work space and is LEED Gold certified by the US Green Building Council. This new space represents the Ragon’s world-class research, and Cambridge’s exceptional biomedical ecosystem, with a beautiful, functional design that includes a childcare center and reserves a third of the site for open, public-use spaces.